Estimation of quantitative genetic parameters

Estimation of quantitative genetic parameters.

This paper gives a short review of the development of genetic parameter estimation over the last 40 years. This shows the development of more statistically and computationally efficient methods that allow the fitting of more biologically appropriate models. Methods have evolved from direct methods based on covariances between relatives to methods based on individual animal models. Maximum-likel...

Estimation of Genetic Parameters

Estimation of Genetic Parameters

In animal breeding, knowledge of the genetic properties of the traits we are interested in is the first prerequisite in establishing a selection programme. Unless we are concerned with traits controlled by single or few genes, in which case we are generally more interested in gene frequencies, estimation of genetic parameters is synonymous with the estimation of variance components. In this con...

Quantitative estimation of recovery parameters after combined action of ionizing radiation and chemical agents

Background: Treatment of ionizing radiation combined with chemical agents can enhance the inactivation of cells. The aim of this study was to determine the parameters involved in the inhibition of cell recovery. Materials and Methods: A mathematical model describing the process of recovery as a decrease in the effective radiation dose was used. The model includes two parameters, recovery consta...

Multivariate estimation of genetic parameters – Quo vadis?

INTRODUCTION Estimation of genetic parameters is one of the basic tasks in quantitative genetics. As recording schemes become more sophisticated and breeding objectives more detailed, the number of traits of interest is increasing continually. This necessitates multivariate analyses considering more than just a few traits simultaneously. Fortunately, we are at a stage were advances in modelling...